Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Identifieur interne : 003058 ( Main/Exploration ); précédent : 003057; suivant : 003059Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Auteurs : H. Li ; N L-S Tang ; P K-S Chan ; C-Y Wang ; D S-C Hui ; C. Luk ; R. Kwok ; W. Huang ; J J-Y Sung ; Q-P Kong ; Y-P ZhangSource :
- Journal of medical genetics [ 1468-6244 ] ; 2008.
Descripteurs français
- KwdFr :
- Chine (ethnologie), Chine (épidémiologie), Chromosomes humains de la paire 19 (génétique), Famille multigénique, Génotype, Humains, Jeune adulte, Lectines de type C (génétique), Molécules d'adhérence cellulaire (génétique), Polymorphisme de nucléotide simple (génétique), Prédisposition génétique à une maladie, Récepteurs de surface cellulaire (génétique), Répétitions minisatellites (génétique), Syndrome respiratoire aigu sévère (ethnologie), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (pathogénicité).
- MESH :
- ethnologie : Chine, Syndrome respiratoire aigu sévère.
- génétique : Chromosomes humains de la paire 19, Lectines de type C, Molécules d'adhérence cellulaire, Polymorphisme de nucléotide simple, Récepteurs de surface cellulaire, Répétitions minisatellites, Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Famille multigénique, Génotype, Humains, Jeune adulte, Prédisposition génétique à une maladie.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Cell Adhesion Molecules (genetics), China (epidemiology), China (ethnology), Chromosomes, Human, Pair 19 (genetics), Genetic Predisposition to Disease, Genotype, Humans, Lectins, C-Type (genetics), Minisatellite Repeats (genetics), Multigene Family, Polymorphism, Single Nucleotide (genetics), Receptors, Cell Surface (genetics), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (ethnology), Severe Acute Respiratory Syndrome (genetics), Young Adult.
- MESH :
- chemical , genetics : Cell Adhesion Molecules, Lectins, C-Type, Receptors, Cell Surface.
- geographic , epidemiology : China.
- geographic , ethnology : China.
- epidemiology : Severe Acute Respiratory Syndrome.
- ethnology : Severe Acute Respiratory Syndrome.
- genetics : Chromosomes, Human, Pair 19, Minisatellite Repeats, Polymorphism, Single Nucleotide, Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- Genetic Predisposition to Disease, Genotype, Humans, Multigene Family, Young Adult.
Abstract
Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR.
DOI: 10.1136/jmg.2008.058966
PubMed: 18697825
Affiliations:
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Le document en format XML
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Li</name></author><author><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N L-S" last="Tang">N L-S Tang</name></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P K-S" last="Chan">P K-S Chan</name></author><author><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C-Y" last="Wang">C-Y Wang</name></author><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S-C" last="Hui">D S-C Hui</name></author><author><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C" last="Luk">C. Luk</name></author><author><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R" last="Kwok">R. Kwok</name></author><author><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W" last="Huang">W. Huang</name></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name></author><author><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q-P" last="Kong">Q-P Kong</name></author><author><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y-P" last="Zhang">Y-P Zhang</name></author></analytic><series><title level="j">Journal of medical genetics</title><idno type="eISSN">1468-6244</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Adhesion Molecules (genetics)</term><term>China (epidemiology)</term><term>China (ethnology)</term><term>Chromosomes, Human, Pair 19 (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Lectins, C-Type (genetics)</term><term>Minisatellite Repeats (genetics)</term><term>Multigene Family</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Receptors, Cell Surface (genetics)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (ethnology)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chine (ethnologie)</term><term>Chine (épidémiologie)</term><term>Chromosomes humains de la paire 19 (génétique)</term><term>Famille multigénique</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Lectines de type C (génétique)</term><term>Molécules d'adhérence cellulaire (génétique)</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Récepteurs de surface cellulaire (génétique)</term><term>Répétitions minisatellites (génétique)</term><term>Syndrome respiratoire aigu sévère (ethnologie)</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Adhesion Molecules</term><term>Lectins, C-Type</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 19</term><term>Minisatellite Repeats</term><term>Polymorphism, Single Nucleotide</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 19</term><term>Lectines de type C</term><term>Molécules d'adhérence cellulaire</term><term>Polymorphisme de nucléotide simple</term><term>Récepteurs de surface cellulaire</term><term>Répétitions minisatellites</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Multigene Family</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Famille multigénique</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P K-S" last="Chan">P K-S Chan</name><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W" last="Huang">W. Huang</name><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S-C" last="Hui">D S-C Hui</name><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q-P" last="Kong">Q-P Kong</name><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R" last="Kwok">R. Kwok</name><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H" last="Li">H. Li</name><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C" last="Luk">C. Luk</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J-Y" last="Sung">J J-Y Sung</name><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N L-S" last="Tang">N L-S Tang</name><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C-Y" last="Wang">C-Y Wang</name><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y-P" last="Zhang">Y-P Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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